The best types of combo decks are ones that you'd never think to combine—surprising not only you, but your opponent too. That's why I love this deck so much. Myutants have the potential to negate your opponent's effects, while Thunder Dragons can completely lock them down and annihilate their board.
Each archetype on its own is pretty great, but I think their true potential lies in being combined with other archetypes to make some pretty crazy combos. If you play your cards just right, you can totally shut down stinkers like Labrynth, Dragonmaid, and even Mathmech.
Because of the number of cards in each archetype, I'm only going to talk about the cards that I use in my deck. You can definitely tweak it as much as you want, and add other support cards that I didn't include.
Boss Monsters
While you can include some generic extra deck monsters, those are mostly for utility. The big boss monsters in this deck are your 4 fusion fellas: two Myutants and two Thunder Dragons. Each archetype has its own dedicated fusion spell, but Myutants also have a trap card that can fuse monsters, and the Thunder Dragon fusion monsters have effects that allow them to be summoned without the spell cards.
Myutant Synthesis: Can destroy a card on the field when summoned and can make itself immune to monster, spell, or trap effects once per turn.
Myutant Ultimus: Negates a card effect once per turn, at the cost of banishing a Myutant card from your hand, field, or graveyard.
Thunder Dragon Colossus: Keeps your opponent from adding cards from their main deck to their hand (but they can still draw cards).
Thunder Dragon Titan: When a Thunder Dragon effect is activated from your hand, destroys one card on the field.
Thunder Dragon Colossus has a great effect that allows it to be summoned by tributing one non-fusion thunder-type effect monster during the turn a Thunder Dragon's effect was activated from the hand. This is the main way that you'll summon Colossus. The easiest combo to achieve this would be:
Use the effect of either Myutant M-05 or ST-46 to banish Thunder Dragondark from your hand.
Once banished, Thunder Dragondark will let you grab any Thunder Dragon card from your deck and add it to your hand—the ideal choice being Thunder Dragonhawk.
Discard Dragonhawk, allowing you to summon to your field the Dragondark that you banished earlier.
You can then use Thunder Dragon Colossus' effect to tribute Dragondark and summon Colossus.
Thunder Dragon Titan has a similar effect, allowing it to be summoned from the extra deck by banishing a thunder-type monster from your hand and a thunder-type fusion monster from your field. It sounds great, but I would rather have both Thunder Dragon fusions on the field at the same time, and normally use Thunder Dragon Fusion to summon Titan.
The two Myutant fusions have some pretty good floating effects. When destroyed, they'll allow you to add a banished Myutant card to your hand—or in the case of Ultimus, up to 3 banished Myutant cards. The two Thunder Dragon fusions don't have floating effects, they instead have protections. Colossus can banish a thunder monster from your GY (graveyard) to protect itself from being destroyed by effect, and Titan can banish 2 cards from your GY to keep it from being destroyed by battle or card effect.
As mentioned earlier, you can mix-in some generic XYZ or link monsters, like Apollousa or Divine Arsenal, purely for utility. But once you get one or two of the boss monsters on the field, your opponent will either surrender or use everything they have to try to break through your defenses.
Dedicated Support
The best part of combining two archetypes is having two pools of support cards. You can almost just use the Thunder Dragon monsters as fodder to trigger Myutant monster effects and still get the full effects of the Thunder Dragons.
Both Myutant M-05 and ST-46 can be used to summon either Myutant Beast or Myutant Arsenal from your deck by tributing M-05 or ST-46 from your field and banishing a monster (for Beast) or trap (for Arsenal) from your hand or field. The ideal opening combo would be the one mentioned earlier, to summon Colossus.
It's crazy how well these two archetypes synergize. In just a few moves, you can lock your opponent out of their deck, and sometimes the duel, with just one combo. With practice and some tinkering, you can come up with some pretty bonkers strategies to completely shut down most kinds of decks.
Let's take a look at some of the best cards that you'll want to include in the deck.
Myutant:
Myutant M-05: When summoned, lets you add a Myutant monster from your deck to your hand.
Myutant St-46: When summoned, lets you add a Myutant spell or trap from your deck to your hand.
Myutant Beast: Cannot be targeted by monster effects. Can negate a spell card effect or activation by banishing 1 card from your hand or field.
Myutant Arsenal: Cannot be targeted by trap effects. Can negate a monster effect by banishing 1 card from your hand or field.
Myutant Fusion: Allows you to fusion summon a Myutant fusion monster from your extra deck by banishing the materials from your hand or field. If your opponent activated an effect during the turn this card was activated, you can also use 1 monster each from your deck and GY as material.
Myutant Cry: Fusion summon a Myutant fusion monster from your extra deck by shuffling the materials that are banished, in your GY, or your field.
Thunder Dragon:
Thunder Dragondark: Can be discarded from the hand to add another Dragondark from your deck to your hand. When banished, lets you add a Thunder Dragon card from your deck to your hand.
Thunder Dragonroar: Can be discarded from the hand to add a Thunder Dragon to your hand that is in your GY or is banished. When banished, allows you to summon a Thunder Dragon monster from your deck.
Thunder Dragonhawk: Can be discarded to special summon a Thunder Dragon that is banished or in your GY. When banished, allows you to shuffle any number of cards from your hand into your deck and draw that same number of cards.
Thunder Dragon Fusion: Fusion summon a Thunder fusion monster from your extra deck by shuffling the fusion material from your banished cards, GY, or your field into your deck.
Your usual plays are going to be using Thunder Dragons as fodder for your Myutant effects, specifically M-05, ST-46, Beast, and Arsenal. With the latter two, you'll negate some effects and even swarm your field, draw some cards, or get a Thunder Dragon from your deck into your hand.
Another gigantic advantage of this deck is the ability to fusion summon using cards in your graveyard or banished cards as fusion material. If you happen to get hit by Nibiru, a Kaiju, or god forbid anything Kashtira, as long as you have Myutant Cry set, you can pretty easily recuperate, even during your opponent's turn. Cards like Myutant Fusion and Thunder Dragon Fusion will not only fusion summon a big boy to the field, but will even recycle your GY and banished cards.
Generic Support
Aside from the usual hand traps (Maxx C, Ash Blossom, and Infinite Impermanence), there's a lot of great generic support to include with this deck. One of the best is Emergency Teleport, which lets you special summon either Myutant M-05 or ST-46 right from your deck and put their primary search effects to good use.
Aloof Lupine can help you trigger the banish effects of Thunder Dragons and further accelerate getting Thunder Dragon Colossus on the field. Just by summoning this wolf, you'll banish Thunder Dragondark from your hand and kick off that whole chain. To accelerate that combo EVEN FURTHER, just slap out a Gold Sarcophagus.
Allure of Darkness is a fantastic card to use in this deck. Not only do you get to draw 2 cards, but you're forced to banish a dark monster in your hand or else discard your entire hand to the GY. You could use this as another easy ticket to Thunder Dragon Colossus by banishing Thunder Dragondark and going down the same route from earlier. Another potential combo would be to banish Necroface using Allure of Darkness's effect which, when banished, makes each player banish the top 5 cards of their decks. Not only would that mess with your opponent's strategies, but you could even end up banishing a Thunder Dragon or two and triggering their effects!
If you're looking to lock the game down even further, running Macro Cosmos will banish any card sent to the GY—monster, spell, or trap. If you manage to have Myutant Beast, Synthesis, or even Ultimus on the field, your opponent will waste precious resources trying to take them out while you negate their card effects. In the same vain, you could run a couple of copies of Mask Change II to completely decimate your opponent and then some.
Activate Mask Change II, send Thunder Dragondark from your field to your GY.
Summon Masked HERO Dark Law from your extra deck using Mask Change II's effect.
Activate the secondary effect of Dragondark, adding Dragonhawk from your deck to your hand.
Activate Dragonhawk's effect by sending it from your hand to the GY.
Special summon Dragondark from your GY.
Activate Thunder Dragon Colossus' effect and special summon it by tributing Dragondark.
Not only have you stopped your opponent from adding cards from their deck to their hand, but Darklaw basically acts as Macro Cosmos, except it only applies to your opponent. You could also use Mask Change II on Myutant M-05 or ST-46 to summon Masked HERO Acid if your opponent has a field stacked with lots of spells and traps that need to be destroyed.
Running a few rank 8 XYZ in your extra deck and also go a long way with going first. Number 38: Hope Harbinger Dragon Titanic Galaxy (what a goddamn mouthful of a name) can easily keep your opponent's spell cards in check. If you're looking for something with more utility, Number 23: Lancelot, Dark Knight of the Underworld can negate spells, traps, monster effects, and can even attack directly. On top of that, when it deals damage, you can destroy one of your opponent's monsters. Pretty sweet.
Final Thoughts
This deck is entirely too much fun. Normal inconveniences like being banished or sent to the GY actually feel like rewards, depending on the monsters. And with so many floodgates at your disposal, your opponents might surrender quite often.
If there's one weakness to this deck, it's anything that negates monster effects. If you're in the middle of a combo and your opponent hits with you an Ash Blossom, Infinite Impermanence, or anything at all that cancels out your monster effects mid-combo, you're toast.
Pros
Benefits from cards being banished.
Plenty of floodgate options.
Easy-peasy fusions.
Very disruptive/ lots of negate effects.
Cons
Very susceptible to monster effect negates and Kaijus.
Very low swarm.
Amazing high-res card art from https://ygoprodeck.com/